circRNA basic information
circBase ID: -
Name: hsa_circ_NTRK2
Synonym: -
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ESCC cell lines (Eca-109, EC-9706, KYSE-30, KYSE-150, TE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NRIP1
Associated microRNA: hsa-miR-140-3p
Biological function: Knockdown of circNTRK2 inhibited ESCC cell proliferation, invasion and epithelial-mesenchymal transition (EMT), and accelerated apoptosis in vitro
Molecular mechanism: regulating hsa-miR-140-3p/NRIP1 pathway
Survival: poor
Supported No.:
 2
Description:

CircNTRK2 promoted ESCC progression by regulating miR-140-3p/NRIP1 pathway. Our findings contribute to a better understanding of circRNAs as miRNA sponges and highlight a promising therapy target in ESCC.
Other information
Title:

Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p.

Journal: J Exp Clin Cancer Res
Published: 2020/7/13
PubMed ID: 32653032