circRNA basic information
circBase ID: -
Name: hsa_circ_VCAN
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OA chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircVCAN is overexpressed in OA tissues and cells. CircVCAN can affect the proliferation and apoptosis of OA chondrocytes by blocking the activation of the NF-kappaB signaling pathway. Thus, CircVCAN may be an important target molecule for OA treatment.
Other information
Title:

CircVCAN regulates the proliferation and apoptosis of osteoarthritis chondrocyte through NF-kappaB signaling pathway.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/7/8
PubMed ID: 32633338