circRNA basic information
circBase ID: -
Name: hsa_circ_FGD4
Synonym: -
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell lines (MKN28, AGS, SGC7901, MKN45, MGC803, BGC823)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: APC/beta-catenin signalling pathway
Associated microRNA: hsa-miR-532-3p
Biological function: suppressed GC cell viability, colony formation, migration, induced epithelial-mesenchymal transition (EMT), and tumorigenesis and metastasis in vivo
Molecular mechanism: sponging hsa-miR-532-3p and enhancing APC expression
Survival: better
Supported No.:
 1
Description:

circFGD4 suppressed GC progression through sponging miR-532-3p and enhancing APC expression to inactivate the beta-catenin signalling. Thus circFGD4 provides a novel potential biomarker and valuable therapeutic strategy for GC.
Other information
Title:

Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/beta-catenin signalling pathway.

Journal: Clin Sci (Lond)
Published: 2020/7/8
PubMed ID: 32633323