circRNA basic information
circBase ID: -
Name: hsa_circ_TIMP2
Synonym: -
Host Gene: hsa-miR-185-5p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-185-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_TIMP2 promoted TNF_alpha_ and IL_1beta_induced NP cell imbalance between ECM anabolism and catabolism via miR_185_5p_MMP2 signaling.
Other information
Title:

Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR_185_5p and matrix metalloproteinase 2.

Journal: Int J Mol Med
Published: 2020/7/7
PubMed ID: 32626912