circRNA basic information
circBase ID: -
Name: hsa_circ_PRKDC
Synonym: -
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human fetal colonic mucosa cells (FHC), CRC cells (SW620, SW480)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: hsa-miR-375
Biological function: Circ-PRKDC silencing repressed 5-FU resistance, cell colony formation and invasion in 5-FU-resistant CRC cells in vitro and inhibited 5-FU resistance in vivo
Molecular mechanism: regulating FOXM1/hsa-miR-375 axis
Survival: -
Supported No.:
 4
Description:

Circ-PRKDC enhanced 5-FU resistance in CRC by regulating FOXM1/miR-375 axis and wnt/beta-catenin pathway.
Other information
Title:

Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/beta-Catenin Pathway.

Journal: Onco Targets Ther
Published: 2020/7/2
PubMed ID: 32606803