circRNA basic information
circBase ID: hsa_circ_0007385
Name: hsa_circ_MEMO1
Synonym: -
Host Gene: hsa-miR-519d-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (A549, HCC827, H1975, H2342)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-519d-3p
Biological function: Silenced circ_0007385 suppressed NSCLC cell proliferation, migration, invasion, and DDP resistance in vitro, and tumor growth in vivo
Molecular mechanism: circ_0007385/hsa-miR-519d-3p/HMGB1
Survival: poor
Supported No.:
 5
Description:

circ_0007385 was upregulated in NSCLC tissues and cells, and was associated with poor overall survival. Silenced circ_0007385 suppressed NSCLC cell proliferation, migration, invasion, and DDP resistance in vitro, and tumor growth in vivo. circ_0007385 was upregulated in NSCLC tissues and cells, and was associated with poor overall survival.
Other information
Title:

circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.

Journal: Thorac Cancer
Published: 2020/7/1
PubMed ID: 32602212