circRNA basic information
circBase ID: hsa_circ_0075686
Name: hsa_circ_ATXN1
Synonym: -
Host Gene: hsa-miR-526b-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line
Sample type details: immortalized human cerebral microvascular endothelial cell line (hCMEC/D3), human glioma (U87MG), human embryonic kidney 293_T cell lines (HEK293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP2
Associated microRNA: hsa-miR-526b-3p
Biological function: Knockdown of SRSF10 or circ-ATXN1 significantly inhibited cell viability, migration and tube formation of GECs
Molecular mechanism: SRSF10/circ-ATXN1/hsa-miR-526b-3p axis
Survival: -
Supported No.:
 1
Description:

SRSF10/circ-ATXN1/miR-526b-3p axis played a crucial role in regulating the angiogenesis of GECs. The above findings provided new targets for anti-angiogenic therapy in glioma.
Other information
Title:

SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.

Journal: J Exp Clin Cancer Res
Published: 2020/7/1
PubMed ID: 32600379