circRNA basic information
circBase ID: hsa_circ_0026134
Name: hsa_circ_TUBA1C
Synonym: -
Host Gene: hsa-miR-143-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (Calu-3, A549), normal bronchus endothelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-143-3p
Biological function: circTUBA1C deficiency notably hampered cell proliferation as well as accelerated cell apoptosis in NSCLC
Molecular mechanism: negatively regulate hsa-miR-143-3p
Survival: -
Supported No.:
 3
Description:

the decline of tumor growth resulted from circTUBA1C deficiency could be recovered by miR-143-3p knockdown. Taken together, these findings indicated the important role of circTUBA1C/miR-143-3p axis in NSCLC, which may provide a potential target for NSCLC therapy.
Other information
Title:

Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.

Journal: Cell Signal
Published: 2020/7/1
PubMed ID: 32599139