circRNA basic information
circBase ID: -
Name: hsa_circ_ABCB10
Synonym: -
Host Gene: hsa-miR-217
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung bronchial epithelial cells (BEAS-2B), NSCLC cells (SPC-A1, A549, HCC827, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-217
Biological function: knocking down circABCB10 remarkably suppressed the proliferation and migration ability of LCa cells
Molecular mechanism: specifically bind to microRNA-217 and negatively regulate its expression
Survival: poor
Supported No.:
 1
Description:

In vitro cell experiments demonstrated that knocking down circABCB10 remarkably suppressed the proliferation and migration ability of LCa cells. In addition, circABCB10 can specifically bind to microRNA-217 and negatively regulate its expression of microRNA-217 in LCa cells. Finally, cell functional experiments showed that microRNA-217 is a key downstream gene that mediates the regulation of circABCB10 on LCa cell function.
Other information
Title:

CircABCB10 promotes the proliferation and migration of lung cancer cells through down-regulating microRNA-217 expression.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/6/24
PubMed ID: 32572881