circRNA basic information
circBase ID: -
Name: hsa_circ_LDLR
Synonym: -
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human thyroid cell line (Nthy-ori3-1), PTC cell lines (K-1, SW1736)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LIPH
Associated microRNA: hsa-miR-195-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

Silencing of circ_LDLR suppressed PTC cell colony formation, proliferation, migration and invasion and promoted apoptosis in vitro and hampered tumor growth in vivo.
Other information
Title:

Circ_LDLR promoted the development of papillary thyroid carcinoma via regulating miR-195-5p/LIPH axis.

Journal: Cancer Cell Int
Published: 2020/6/19
PubMed ID: 32549788