circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_102958
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OC cell lines (IOSE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SH2D3A
Associated microRNA: hsa-miR-1205
Biological function: Knockdown of hsa_circRNA_102958 significantly suppressed the proliferation, migration and invasion of OC cells and vice versa.
Molecular mechanism: inhibited hsa-miR-1205 activity to promote SH2D3A expression
Survival: poor
Supported No.:
 1
Description:

Knockdown of hsa_circRNA_102958 significantly suppressed the proliferation, migration and invasion of OC cells and vice versa. hsa_circRNA_102958 was a competing endogenous RNA (ceRNA) for miR-1205. hsa_circRNA_102958 inhibited miR-1205 activity to promote SH2D3A expression. Overexpression of SH2D3A promoted proliferation, migration and invasion of OC cells.
Other information
Title:

Upregulation of hsa_circRNA_102958 Indicates Poor Prognosis and Promotes Ovarian Cancer Progression Through miR-1205/SH2D3A Axis.

Journal: Cancer Manag Res
Published: 2020/6/18
PubMed ID: 32547237