circRNA basic information
circBase ID: -
Name: hsa_circ_Gprc5a
Synonym: -
Host Gene: hsa-miR-1283
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (MHCC97, PLC, SK-Hep1, Huh7, Hep3B, HepG2), human normal liver cell lines (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1/TEAD1 Signalling Pathway
Associated microRNA: hsa-miR-1283
Biological function: Knockout of circGprc5a inhibited proliferation of HCC and induced apoptosis
Molecular mechanism: activated the YAP1/TEAD1 signaling pathway by acting as a sponge for hsa-miR-1283
Survival: poor
Supported No.:
 1
Description:

Knockout of circGprc5a inhibited proliferation of HCC and induced apoptosis. CircGprc5a activated the YAP1/TEAD1 signaling pathway by acting as a sponge for miR-1283. Furthermore, overexpression of miR-1283 abolished the promotion of circGprc5a on HCC cells.

Other information
Title:

Circular RNA Gprc5a Promotes HCC Progression by Activating YAP1/TEAD1 Signalling Pathway by Sponging miR-1283.

Journal: Onco Targets Ther
Published: 2020/6/18
PubMed ID: 32547082