circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF566
Synonym: -
Host Gene: hsa-miR-4738-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal liver cell line (Lo2), hepatoma cell lines (Huh7, QSG-7701, Hep3B, HepG2, MHCC-97L, MHCC97H, MHCC-LM3)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: TDO2
Associated microRNA: hsa-miR-4738-3p
Biological function: promoted HCC cell migration, invasion, and proliferation
Molecular mechanism: acted as a hsa-miR-4738-3p sponge to relieve the repressive effect of hsa-miR-4738-3p on its target TDO2
Survival: poor
Supported No.:
 1
Description:

High circZNF566 expression in HCC tissues was positively correlated with clinicopathological features and poor prognosis. Functionally, in vitro experiments showed that circZNF566 promoted HCC cell migration, invasion, and proliferation, whereas in vivo experiments showed that circZNF566 promoted tumorigenesis and metastasis.

Other information
Title:

Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression.

Journal: Cell Death Dis
Published: 2020/6/14
PubMed ID: 32532962