circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: -
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human RCC lines (ACHN, 786-O, 769-P, A498, Caki1, Caki2), human renal epithelial cell lines (HK2, 293 T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CBX4
Associated microRNA: hsa-miR-136-5p
Biological function: promotes the proliferation and metastasis
Molecular mechanism: sponging hsa-miR-136-5p
Survival: poor
Supported No.:
 1
Description:

circTLK1 plays a critical role in RCC progression by sponging miR-136-5p to increase CBX4 expression. circTLK1 may act as a diagnostic biomarker and therapeutic target for RCC.
Other information
Title:

CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p.

Journal: Mol Cancer
Published: 2020/6/7
PubMed ID: 32503552