circRNA basic information
circBase ID: -
Name: hsa_circ_TP53
Synonym: -
Host Gene: hsa-miR-1233-3p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human thyroid cancer cell line (TPC-1), human papillary thyroid cancer cell line (MDA-T32)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM2
Associated microRNA: hsa-miR-1233-3p
Biological function: promoted cell proliferation and cell viability
Molecular mechanism: acted as a target of hsa-miR-1233-3p to increase MDM2 expression
Survival: -
Supported No.:
 1
Description:

overexpressed circTP53 decreased the protein level of p53 via targeting miR-1233-3p/MDM2 axis and promoted cancer cell proliferation.
Other information
Title:

CircTP53 promotes the proliferation of thyroid cancer via targeting miR-1233-3p/MDM2 axis.

Journal: J Endocrinol Invest
Published: 2020/6/6
PubMed ID: 32500444