circRNA basic information
circBase ID: -
Name: hsa_circ_RUNX1
Synonym: -
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cells (SW480, SW620, HCT116, HT29, LoVo, RKO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1
Associated microRNA: hsa-miR-145-5p
Biological function: circRUNX1 knockdown inhibited cell proliferation and migration and promoted apoptosis, whereas its overexpression exerted opposite effects.
Molecular mechanism: circRUNX1 competitively bound to hsa-miR-145-5p and prevented hsa-miR-145-5p from decreasing the expression of IGF1
Survival: poor
Supported No.:
 2
Description:

circRUNX1 functions as a tumor promotor in CRC cells by targeting the miR-145-5p/IGF1 signaling pathway and may have potential use as a prognostic indicator and therapeutic target in CRC patients.
Other information
Title:

Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling.

Journal: Onco Targets Ther
Published: 2020/6/5
PubMed ID: 32494158