circRNA basic information
circBase ID: hsa_circ_0043800
Name: hsa_circ_STAT3
Synonym: -
Host Gene: hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p
 
 
 
Disease basic information
DO ID:
 687
DO name: hepatoblastoma
Disease details: hepatoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HB cell lines (HepG2, HuH-6), human normal liver cell line (THLE-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3/Gli2
Associated microRNA: hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p
Biological function: silencing of circ-STAT3 led to the inhibition on HB cell growth, migration and stem-cell characteristics.
Molecular mechanism: acting as a sponge for hsa-miR-29a/b/c-3p to upregulate STAT3/Gli2
Survival: -
Supported No.:
 1
Description:

Gli2-induced circ_0043800 served as the ceRNA to promote HB by up-regulation of STAT3 and Gli2 at a miR-29a/b/c-3p dependent manner.
Other information
Title:

Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2.

Journal: J Exp Clin Cancer Res
Published: 2020/6/5
PubMed ID: 32493490