circRNA basic information
circBase ID: -
Name: hsa_circ_SATB2
Synonym: -
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Immortalized human bronchial epithelial cells (BEAS-2B), human lung cancer cell lines (A549, H460, H1299, H226, MES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FSCN1
Associated microRNA: hsa-miR-326
Biological function: circSATB2 can be transferred by exosomes and promote the proliferation, migration and invasion of NSCLC cells, as well as induce abnormal proliferation in normal human bronchial epithelial cells.
Molecular mechanism: positively regulated fascin homolog 1, actin-bundling protein 1 (FSCN1) expression via hsa-miR-326
Survival: -
Supported No.:
 2
Description:

circSATB2 participated in the progression of NSCLC and was differentially expressed in lung cancer tissue and serumal exosomes. circSATB2 may be potential biomarker for the diagnosis of NSCLC.
Other information
Title:

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.

Journal: Mol Cancer
Published: 2020/6/5
PubMed ID: 32493389