circRNA basic information
circBase ID: hsa_circ_0085131
Name: hsa_circ_PABPC1
Synonym: -
Host Gene: hsa-miR-654-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (H1975, H820, H1299, H358), human normal lung cell line (BESA_2B), DDP sensitive human NSCLC cell line (A549), DDP resistant strain (A549/DDP)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATG7
Associated microRNA: hsa-miR-654-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

hsa_circ_0085131 enhances DDP-resistance of NSCLC cells through sequestering miR-654-5p to upregulate ATG7, leading to cell autophagy.
Other information
Title:

Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy.

Journal: Cell Biol Int
Published: 2020/5/26
PubMed ID: 32449799