circRNA basic information
circBase ID: hsa_circ_0000515
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-296-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human mammary epithelial cell line (MCF-10A), human BC cell lines (MDA-MB-231, SUM-159, MCF-7, SK-BR-3, MDA-MB-157)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCL10
Associated microRNA: hsa-miR-296-5p
Biological function: Silencing of hsa_circ_0000515 impaired cell cycle progression, cell proliferation, and invasion, attenuated inflammatory response, and reduced the proangiogenetic potential of BC cells.
Molecular mechanism: microRNA-296-5p/CXCL10 axis
Survival: poor
Supported No.:
 9
Description:

Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis.
Other information
Title:

Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis.

Journal: FEBS J
Published: 2020/5/24
PubMed ID: 32446265