circRNA basic information
circBase ID: hsa_circ_0043265
Name: hsa_circ_ACACA
Synonym: -
Host Gene: hsa-miR-25-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cells (A549, NCI-H23, NCI-H1299, HCC827), human normal lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FOXP2
Associated microRNA: hsa-miR-25-3p
Biological function: inhibited the proliferation, migration, invasion and EMT process, while improved the apoptosis of NSCLC cells
Molecular mechanism: sponge hsa-miR-25-3p to improve FOXP2 expression
Survival: -
Supported No.:
 3
Description:

Hsa_circ_0043265 could sponge miR-25-3p to improve FOXP2 expression, thereby inhibiting NSCLC progression. This study showed that hsa_circ_0043265 could be a potential biomarker for early diagnosis of NSCLC.
Other information
Title:

Hsa_circ_0043265 Suppresses Proliferation, Metastasis, EMT and Promotes Apoptosis in Non-Small Cell Lung Cancer Through miR-25-3p/FOXP2 Pathway.

Journal: Onco Targets Ther
Published: 2020/5/23
PubMed ID: 32440153