circRNA basic information
circBase ID: -
Name: hsa_circ_MDM2
Synonym: -
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OSCC cell lines (SCC25, CAL27), normal oral keratinocytes (NHOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: hsa-miR-532-3p
Biological function: promotes the proliferation and glycolysis of OSCC
Molecular mechanism: sponged hsa-miR-532-3p
Survival: -
Supported No.:
 1
Description:

Mechanistically, circMDM2 sponged miR-532-3p to promote the hexokinase 2 (HK2), forming the circMDM2/miR-532-3p/HK2 axis. In conclusion, these findings demonstrated that circMDM2/miR-532-3p/HK2 axis promotes the proliferation and glycolysis of OSCC, rendering a potential diagnostic biomarker and prospective therapeutic target for OSCC.
Other information
Title:

Circular RNA circMDM2 accelerates the glycolysis of oral squamous cell carcinoma by targeting miR-532-3p/HK2.

Journal: J Cell Mol Med
Published: 2020/5/16
PubMed ID: 32410389