circRNA basic information
circBase ID: hsa_circ_0000337
Name: -
Synonym: circ_0000337
Host Gene: hsa-miR-4458
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: cell line
Sample type details: human OS cell lines (U2OS, HOS, 143B, MG-63), human noncancerous osteoplas tic cell line (NHOst), human osteoblastic cell line (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BACH1
Associated microRNA: hsa-miR-4458
Biological function: promote cell proliferation and migration
Molecular mechanism: sponged hsa-miR-4458 to elevate BACH1 expression
Survival: -
Supported No.:
 1
Description:

Circ_0000337 promoted OS progression via sponging miR-4458 and thus elevating BACH1 expression, offering rational therapeutic target for OS.
Other information
Title:

Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway.

Journal: Cancer Biomark
Published: 2020/5/12
PubMed ID: 32390598