circRNA basic information
circBase ID: hsa_circ_0001368
Name: hsa_circ_KLHL24
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3829
DO name: pituitary adenoma
Disease details: pituitary adenoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: knockdown of hsa_circ_0001368 significantly inhibited the proliferation, invasion and GH secreting level of GHPA primary culture cells
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Among these differentially expressed circRNAs, hsa_circ_0001368 was verified significant up-regulated by qRT-PCR, which was specific up-regulated in GHPA and correlated with the invasiveness and serum GH level of GHPA; functional studies indicated that knockdown of hsa_circ_0001368 significantly inhibited the proliferation, invasion and GH secreting level of GHPA primary culture cells. Moreover, hsa_circ_0001368 had a significant positive correlation with the pituitary-specific transcription factor Pit-1.
Other information
Title:

Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development.

Journal: Brain Res Bull
Published: 2020/5/12
PubMed ID: 32389802