circRNA basic information
circBase ID: hsa_circ_0009065
Name: hsa_circ_BFAR
Synonym: -
Host Gene: hsa-miR-34b-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: pancreatic epithelial cells (hTERT-HPNE), PDAC cells (BxPC-3, MIA PaCa-2, CFPAC-1, PANC-1)
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MET/Akt axis
Associated microRNA: hsa-miR-34b-5p
Biological function: circBFAR knockdown dramatically inhibited the proliferation and motility of PDAC cells in vitro and their tumor-promoting and metastasis properties in in vivo models
Molecular mechanism: increased the expression of MET and activated downstream phosphorylation of Akt (Ser 473) and further activated the MET/PI3K/Akt signaling pathway
Survival: -
Supported No.:
 1
Description:

Our findings showed that circBFAR plays an important role in the proliferation and metastasis of PDAC, which might be explored as a potential prognostic marker and therapeutic target for PDAC.
Other information
Title:

Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis.

Journal: Mol Cancer
Published: 2020/5/8
PubMed ID: 32375768