circRNA basic information
circBase ID: hsa_circ_0002018
Name: hsa_circ_NFIC
Synonym: -
Host Gene: hsa-miR-658
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MDA-MB-468, MDA-MB-231
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: UPK1A
Associated microRNA: hsa-miR-658
Biological function: suppressed breast cancer cell proliferation and migration
Molecular mechanism: acted as a sponge for hsa-miR-658 and competed for binding to hsa-miR-658 with UPK1A, leading to increased expression of UPK1A.
Survival: better
Supported No.:
 1
Description:

Our study highlighted the regulatory function of the circNFIC/miR-658/UPK1A pathway in breast cancer progression, which could be a potential therapeutic target for breast cancer.
Other information
Title:

circNFIC suppresses breast cancer progression by sponging miR-658.

Journal: J Cancer
Published: 2020/5/6
PubMed ID: 32368305