circRNA basic information
circBase ID: -
Name: hsa_circ_FAM169A
Synonym: -
Host Gene: hsa-miR-583
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NP cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-583
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

circ-FAM169A sequestered miR-583, which could potentially upregulate BTRC, an inducer of the NF-kappaB signaling pathway. In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling.
Other information
Title:

The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC.

Journal: Cell Death Dis
Published: 2020/5/6
PubMed ID: 32366862