circRNA basic information
circBase ID: hsa_circ_0000745
Name: -
Synonym: circ-0000745
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9952
DO name: acute lymphoblastic leukemia
Disease details: acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: human leukemia cell line (Kasumi-1, KG-1 cells), human primary T lymphocytes Cells (T cell)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ERK pathway
Associated microRNA: -
Biological function: enhanced the proliferation of Kasumi-1 and KG-1 cells, and reduced the ratio of apoptosis cells
Molecular mechanism: increasing the activation of ERK pathway
Survival: -
Supported No.:
 2
Description:

upregulated circ-0000745 in leukemia cells could promoter cell viability by increasing the activation of ERK pathway.
Other information
Title:

Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.

Journal: Gene
Published: 2020/5/4
PubMed ID: 32360844