circRNA basic information
circBase ID: -
Name: hsa_circ_Cznf532
Synonym: Cznf532
Host Gene: hsa-miR-29a-3p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: diabetic retinopathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human retinal pericytes (ACBRI-183), HRVECs (ACBRI-181)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-29a-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

these data identify a circRNA-mediated mechanism that coordinates pericyte biology and vascular homeostasis in DR. Induction of cZNF532 or antagonism of miR-29a-3p is an exploitable therapeutic approach for the treatment of DR.
Other information
Title:

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.

Journal: J Clin Invest
Published: 2020/4/29
PubMed ID: 32343678