circRNA basic information
circBase ID: hsa_circ_0000260
Name: hsa_circ_SMC3
Synonym: -
Host Gene: hsa-miR-4720-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric cell lines (AGS, GES_1, MGC_803, BGC_823, SGC_7901)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: TJP1
Associated microRNA: hsa-miR-4720-3p
Biological function: loss of circSMC3 abolished the proliferation and motility of gastric cancer cells
Molecular mechanism: circSMC3 decreased hsa-miR-4720-3p expression by acting as a miRNA sponge, and tight junction protein 1 (TJP1) 3UTR was identified to be the target of hsa-miR-4720-3p, contributing to a circSMC3/hsa-miR-4720-3p/TJP1 axis
Survival: poor
Supported No.:
 1
Description:

circSMC3 decreased miR-4720-3p expression by acting as a miRNA sponge, and tight junction protein 1 (TJP1) 3UTR was identified to be the target of miR-4720-3p, contributing to a circSMC3/miR-4720-3p/TJP1 axis. Thus, our results indicate that circSMC3 promotes gastric cancer cell proliferation and motility through miR-4720-3p/TJP1.
Other information
Title:

CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis.

Journal: Cancer Med
Published: 2020/4/22
PubMed ID: 32314520