circRNA basic information
circBase ID: -
Name: mmu_circ_FBXW4
Synonym: -
Host Gene: mmu-miR-18b-3p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: hepatic fibrosis
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: primary liver cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: FBXW7
Associated microRNA: mmu-miR-18b-3p
Biological function: inhibited HSCs activation, proliferation and induced apoptosis, attenuated mouse liver fibrogenesis injury and showed anti-inflammation effect
Molecular mechanism: directly targeted to mmu-miR-18b-3p to regulate the expression of FBXW7 in HF.
Survival: -
Supported No.:
 1
Description:

We found that circFBXW4 downregulated in liver fibrogenesis. Enforcing the expression of circFBXW4 inhibited HSCs activation, proliferation and induced apoptosis, attenuated mouse liver fibrogenesis injury and showed anti-inflammation effect. Mechanistically, circFBXW4 directly targeted to miR-18b-3p to regulate the expression of FBXW7 in HF. Conclusions: circFBXW4 may act as a suppressor of HSCs activation and HF through the circFBXW4/miR-18b-3p/FBXW7 axis. Our findings identify that circFBXW4 serves as a potential biomarker for HF therapy.
Other information
Title:

Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis.

Journal: Theranostics
Published: 2020/4/21
PubMed ID: 32308754