circRNA basic information
circBase ID: hsa_circ_0004846
Name: -
Synonym: hsa_circ_0004846
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 9970
DO name: obesity
Disease details: obesity
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Preadipocyte were isolated from visceral adipose tissues (VAT)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: EZH2
Associated microRNA: hsa-miR-138-5p
Biological function: controls adipogenesis in obesity
Molecular mechanism: acting as a hsa-miR-138-5p sponge, and thus increasing EZH2 expression
Survival: poor
Supported No.:
 1
Description:

CircSAMD4A regulated preadipocyte differentiation by acting as a miR-138-5p sponge, and thus increasing EZH2 expression. These results suggested that circSAMD4A can serve as a potential target for obesity treatments and/or as a potential prognostic marker for obese patients following bariatric surgery.
Other information
Title:

Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis.

Journal: Theranostics
Published: 2020/4/16
PubMed ID: 32292524