circRNA basic information
circBase ID: -
Name: hsa_circ_PRRC2A
Synonym: -
Host Gene: hsa-miR-514a-5p, hsa-miR-6776-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RCC cell lines (ACHN, Caki-1, Caki-2, 786-o), human umbilical vein endothelial cells (HUVECs) A-498, 769-P, A-704
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: TRPM3
Associated microRNA: hsa-miR-514a-5p, hsa-miR-6776-5p
Biological function: promotes angiogenesis and metastasis
Molecular mechanism: prevents the degradation of TRPM3, a tissue-specific oncogene, mRNA by sponging hsa-miR-514a-5p and hsa-miR-6776-5p
Survival: -
Supported No.:
 1
Description:

our results indicate that circPRRC2A prevents the degradation of TRPM3, a tissue-specific oncogene, mRNA by sponging miR-514a-5p and miR-6776-5p. Moreover, circPRRC2A promotes tumor EMT and aggressiveness in patients with RCC.
Other information
Title:

circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma.

Journal: Theranostics
Published: 2020/4/16
PubMed ID: 32292503