circRNA basic information
circBase ID: hsa_circ_0000285
Name: -
Synonym: circ_0000285
Host Gene: hsa-miR-654-3p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Immortalized mouse podocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAPK6
Associated microRNA: hsa-miR-654-3p
Biological function: promotes podocyte injury
Molecular mechanism: sponging hsa-miR-654-3p and activating MAPK6
Survival: -
Supported No.:
 1
Description:

MAPK6 was markedly suppressed by circ_0000285 siRNA, which was rescued by the decrease of miR-654-3p. These findings revealed that circ_0000285 promoted podocyte injury via sponging miR-654-3p and activating MAPK6 in DN.
Other information
Title:

Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.

Journal: Gene
Published: 2020/4/11
PubMed ID: 32275999