circRNA basic information
circBase ID: -
Name: hsa_circ_SCARB1
Synonym: -
Host Gene: hsa-miR-510-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RCC cell lines (786-O, 769-P, A498, A704)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SDC3
Associated microRNA: hsa-miR-510-5p
Biological function: Knockdown of Circ-SCARB1 inhibited cell proliferation, migration, and invasion while inducing cell apoptosis
Molecular mechanism: sequestering hsa-miR-510-5p and indirectly up-regulating SDC3 expression
Survival: -
Supported No.:
 1
Description:

Circ-SCARB1 promotes RCC progression via sequestering miR-510-5p and indirectly up-regulating SDC3 expression. This provides a novel perspective for the pathogenesis of RCC and potential therapeutic targets for the treatment of RCC.
Other information
Title:

CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis.

Journal: Curr Cancer Drug Targets
Published: 2020/4/10
PubMed ID: 32271695