circRNA basic information
circBase ID: -
Name: hsa_circ_KIF4A
Synonym: -
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human astrocytes (NHAs), human glioma cell lines (LN229, A172, SHG44, U251)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Wnt5a signaling
Associated microRNA: hsa-miR-139-3p
Biological function: Knockdown of circKIF4A inhibited the colony formation ability, migration and invasion, and promoted the apoptosis of glioma cells by regulating miR-139-3p
Molecular mechanism: targeting hsa-miR-139-3p to activate Wnt5a signaling
Survival: -
Supported No.:
 2
Description:

circKIF4A was overexpressed in glioma, and knockdown of circKIF4A suppressed glioma progression via miR-139-3p/Wnt5a axis. The results indicated that circKIF4A may be a potential target for clinical treatment of glioma.
Other information
Title:

circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling.

Journal: Mol Med
Published: 2020/4/10
PubMed ID: 32268875