circRNA basic information
circBase ID: hsa_circ_0000527
Name: -
Synonym: circ_0000527
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RB cell lines (Y79, HXO-RB44, SO-Rb50, WERI-Rb-1), normal retinal epithelial cells (ARPE-19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BCL-2
Associated microRNA: hsa-miR-646
Biological function: promoted the viability, migration and invasion
Molecular mechanism: sponged hsa-miR-646 to regulate the expression of BCL-2
Survival: -
Supported No.:
 5
Description:

Expression level of circ_0000527 in RB samples was significantly up-regulated compared to normal tissues, while miR-646 was markedly down-regulated. Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR-646 transfection had the opposite effects. Circ_0000527 sponged miR-646 to regulate the expression of BCL-2.
Other information
Title:

Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis.

Journal: Cell Biochem Funct
Published: 2020/4/9
PubMed ID: 32266733