circRNA basic information
circBase ID: hsa_circ_0005320
Name: hsa_circ_SEPT9
Synonym: -
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human TNBC cell lines (MDA-MB-231, BT-549, MDA-MB-468, MDA-MB-453, SUM-159), normal breast epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F1 and EIF4A3 LIF
Associated microRNA: hsa-miR-637
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

the circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer through circSEPT9/miR-637/LIF axis. Therefore, circSEPT9 could be used as a potential prognostic marker and therapeutical target for TNBC.
Other information
Title:

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer.

Journal: Mol Cancer
Published: 2020/4/9
PubMed ID: 32264877