circRNA basic information
circBase ID: -
Name: hsa_circ_ARF3
Synonym: circ_ARF3
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: osteosarcoma cell lines (Saos2, U2OS, MG-63)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: hsa-miR-1299
Biological function: promoted cell proliferation
Molecular mechanism: acts as a sponge of hsa-miR-1299 to inhibit hsa-miR-1299 mediated CDK6 downregulation
Survival: -
Supported No.:
 1
Description:

in the OS, highly expressed circ_ARF3 acts as a sponge of miR-1299 to inhibit miR-1299 mediated CDK6 downregulation which further promoted OS pathogenesis. circ_ARF3 could be a potential target for OS treatment in the future.
Other information
Title:

circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression.

Journal: Cell Signal
Published: 2020/4/3
PubMed ID: 32240746