circRNA basic information
circBase ID: hsa_circ_0000495
Name: hsa_circ_MYCBP2
Synonym: -
Host Gene: hsa-miR-488-3p
 
 
 
Disease basic information
DO ID:
 5520
DO name: head and neck squamous cell carcinoma
Disease details: head and neck squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human head, neck cancer cell lines (FaDu, SCC-22, SCC-9), NOE cells (normal oral epithelial cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TROP2
Associated microRNA: hsa-miR-488-3p
Biological function: promoted tumor cell proliferation, migration, invasion, and tumor growth
Molecular mechanism: circ-0000495/hsa-miR-488-3p/TROP2
Survival: poor
Supported No.:
 1
Description:

Our study unraveled a novel mechanism by which down-regulation of miR-488-3p sponged by circ-0000495 releases its epigenetic silencing to TROP2. The increased TROP2 promotes tumor proliferation, therefore, providing evidence in support of targeting the circ-0000495/miR-488-3p/TROP2 axis in contributing to HNSCC therapy and preventing tumor metastasis.
Other information
Title:

miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development.

Journal: J Cancer
Published: 2020/4/2
PubMed ID: 32231744