circRNA basic information
circBase ID: hsa_circ_0000467
Name: hsa_circ_SKA3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human non-tumor cell lines (HaCaT, 293T, Jurkat, MCF10A), breast cancer cell lines (MCF-7, MDA-MB-468, MDA-MB-231, HTB126, SK-BR-3), other tumor cell lines (H460, LnCap, Du145, PC3, SNU449, HepG2, CI3K, A549, HeLa)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: Tks5 and integrin beta1
Associated microRNA: -
Biological function: Promotes Breast Cancer Cell Migration and Invasion
Molecular mechanism: complexing with Tks5 and integrin beta1
Survival: -
Supported No.:
 2
Description:

the circular RNA circSKA3 promotes tumor progression by complexing with Tks5 and integrin beta1, inducing invadopodium formation.
Other information
Title:

The Circular RNA circSKA3 Binds Integrin beta1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion.

Journal: Mol Ther
Published: 2020/4/2
PubMed ID: 32229309