circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_0000638
Host Gene: hsa-miR-498-5p
 
 
 
Disease basic information
DO ID:
 1176
DO name: bronchial disease
Disease details: neodymium oxide-induced bronchial epithelial cell inflammation
Species: human
Species details: human
Sample type: cell line
Sample type details: human bronchial epithelial cell line (16HBE), human embryonic kidney cells (293-T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NF-kappaB
Associated microRNA: hsa-miR-498-5p
Biological function: inhibits neodymium oxide-induced bronchial epithelial cell inflammation
Molecular mechanism: regulating hsa-miR-498-5p/NF-kappaB axis
Survival: -
Supported No.:
 1
Description:

Circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.
Other information
Title:

circ_0000638 inhibits neodymium oxide-induced bronchial epithelial cell inflammation through the miR-498-5p/NF-kappaB axis.

Journal: Ecotoxicol Environ Saf
Published: 2020/3/22
PubMed ID: 32199215