circRNA basic information
circBase ID: hsa_circ_0033550
Name: -
Synonym: circ-0033550
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CC cell lines (HeLa, CaSki, SiHa, C33A), 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT1
Associated microRNA: hsa-miR-942-5p
Biological function: promoted CC cell proliferation and invasion
Molecular mechanism: Upregulate AKT1
Survival: -
Supported No.:
 1
Description:

we illustrated that circ-AKT1 upregulated AKT1 by sponging miR-942-5p. Rescue assays confirmed the role of the circ-AKT1/miR-942-5p/AKT1 axis in CC progression. In vivo assays validated that circ-AKT1 promoted tumor growth in CC. Overall, circRNA-AKT1 sequestered miR-942-5p to upregulate AKT1 and promote CC progression, which may offer a new molecular target for the treatment improvement of CC.
Other information
Title:

circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression.

Journal: Mol Ther Nucleic Acids
Published: 2020/3/21
PubMed ID: 32193155