circRNA basic information
circBase ID: -
Name: hsa_circ_PIP5K1A
Synonym: -
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: The GC cell lines (MKN45, AGS, BGC823, MGC803, SGC7901), normal gastric mucosa epithelial cells (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KRT80 and PI3K/AKT pathway
Associated microRNA: hsa-miR-671-5p
Biological function: promote cell proliferation, invasion, migration and EMT
Molecular mechanism: directly interacted with hsa-miR-671-5p to modulate KRT80 expression
Survival: -
Supported No.:
 2
Description:

CircPIP5K1A/miR-671-5p/KRT80 axis contributes to GC progression through PI3K/AKT pathway, implying this axis may be a potential therapeutic target for the treatment of GC patients.
Other information
Title:

CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p.

Journal: Biomed Pharmacother
Published: 2020/3/15
PubMed ID: 32169757