circRNA basic information
circBase ID: -
Name: hsa_circ_PGAM1
Synonym: -
Host Gene: hsa-miR-542-3p
 
 
 
Disease basic information
DO ID:
 2152
DO name: ovary epithelial cancer
Disease details: epithelial ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian cancer cell lines (CAOV3, SKOV3, OVCAR3, ES_2), human embryonic kidney (HEK) 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDC5L/PEAK1
Associated microRNA: hsa-miR-542-3p
Biological function: Silencing of circ-PAGM1 inhibited proliferation, migration, and invasion of ovarian cancer cells and promoted cell apoptosis
Molecular mechanism: circ-PGAM1/hsa-miR-542-3p/CDC5L/PEAK1 pathway
Survival: -
Supported No.:
 1
Description:

The circ-PGAM1/miR-542-3p/CDC5L/PEAK1 pathway played an important role in the progression of ovarian cancer and might be a novel therapeutic target for ovarian cancer.
Other information
Title:

Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway.

Journal: Cancer Med
Published: 2020/3/14
PubMed ID: 32167655