circRNA basic information
circBase ID: -
Name: hsa_circ_CBFB
Synonym: -
Host Gene: hsa-miR-28-5p
 
 
 
Disease basic information
DO ID:
 7693
DO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: human
Species details: human
Sample type: cell line
Sample type details: human aortic line (VSMC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LYPD3 and GRIA4
Associated microRNA: hsa-miR-28-5p
Biological function: circCBFB modulated VSMC apoptosis and proliferation
Molecular mechanism: sponged hsa-miR-28-5p for LYPD3 and GRIA4 elevation
Survival: -
Supported No.:
 1
Description:

MiR-28-5p acted as an apoptosis driver while circCBFB, GRIA4 and LYPD3 exerted anti-apoptosis effects in VSMCs. Mechanically, GRIA4 and LYPD3 were suppressed by miR-28-5p. Moreover, circCBFB served as a sponge of miR-28-5p, releasing GRIA4 and LYPD3 from miR-28-5p suppression. Functionally, GRIA4, LYPD3 and miR-28-5p were required in circCBFB-mediated VSMC apoptosis. SIGNIFICANCE: This work unveiled an innovative axis of circCBFB/miR-28-5p/GRIA4/LYPD3 in VSMC apoptosis, exerting its potential in providing new thoughts in AAA management.
Other information
Title:

CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4.

Journal: Life Sci
Published: 2020/3/11
PubMed ID: 32151690