circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_103762
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal lung cell line (Beas_2B), NSCLC cell lines (A549, NCI_H1299, H1650, H358)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promote cell proliferation, migration, invasion and multidrug resistance
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Together, we demonstrated that circRNA_103762 is upregulated in NSCLC and functions as an oncogene in NSCLC, and circRNA_103762 enhanced MDR by inhibited CHOP expression in NSCLC cells. These results will help us understand the MDR of NSCLC, providing better effective therapy strategies for patients.
Other information
Title:

CircRNA_103762 promotes multidrug resistance in NSCLC by targeting DNA damage inducible transcript 3 (CHOP).

Journal: J Clin Lab Anal
Published: 2020/3/3
PubMed ID: 32118311