circRNA basic information
circBase ID: -
Name: hsa_circ_ACTR2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: immortalized human renal proximal tubular epithelial cell line (HK-2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

our study identified a new circRNA, circACTR2, that regulates high glucose-induced pyroptosis, inflammation and fibrosis in proximal tubular cells. The present study preliminarily explores the role of circRNAs in pyroptosis of tubular cells, and provides novel insight into the pathogenesis of DKD and new therapeutic strategies.
Other information
Title:

circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis.

Journal: Biol Pharm Bull
Published: 2020/3/3
PubMed ID: 32115515