circRNA basic information
circBase ID: -
Name: hsa_circ_CIDN
Synonym: -
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NP cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT1
Associated microRNA: hsa-miR-34a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our results revealed that circRNA-CIDN binding to miR-34a-5p played an important role in mitigating compression loading-induced nucleus pulposus cell damage via targeting SIRT1, providing a potential therapeutic strategy for IDD treatment.
Other information
Title:

CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

Journal: EBioMedicine
Published: 2020/3/3
PubMed ID: 32114390