circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: hsa-miR-545
 
 
 
Disease basic information
DO ID:
 4676
DO name: uremia
Disease details: uremia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human tubule epithelial cells (HK2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: zinc finger E-box-binding homeobox 2 (ZEB2)
Associated microRNA: hsa-miR-545
Biological function: relieves lipopolysaccharide-induced HK2 cell injury
Molecular mechanism: upregulating the expression of hsa-miR-545 target gene ZEB2
Survival: -
Supported No.:
 1
Description:

This research indicated that the highly expressed circPRKCI relieved inflammatory injury induced by LPS in HK2 cells by suppressing miR-545/ZEBs and depressing the briskness of NF-kB pathway.
Other information
Title:

CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.

Journal: Biofactors
Published: 2020/2/28
PubMed ID: 32104945